Chemicals and Drugs

Corticotropin-Like Intermediate Lobe Peptide

A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS. Its sequence is identical to the C-terminal 22-amino acids of ACTH or ACTH 18-39.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS. Its sequence is identical to the C-terminal 22-amino acids of ACTH or ACTH 18-39.

Chemical Identity

Chemical Information

Molecular Formula
C112H165N27O36
Molecular Weight
2465.7 g/mol
IUPAC Name
4-[2-[[2-[[2-[[2-[[2-[2-[[2-[[4-amino-2-[[1-[2-[[2-[[6-amino-2-[[2-[[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]acetyl]amino]propanoylamino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]propanoylamino]-5-[[1-[[1-[2-[[1-[[4-carboxy-1-[(1-carboxy-2-phenylethyl)amino]-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
InChIKey
ZYDMZKPAPSZILB-UHFFFAOYSA-N
SMILES
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC(=N)N)N
MeSH Unique ID
D053497
Source
PubChem CID 16133227

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • ACTH(18-39)
  • CLILP
  • CLIP (ACTH 18-39)
  • Corticotropin Like Intermediate Lobe Peptide
  • ACTHalpha(18-39), Ser(31)-
  • ACTHalpha(18-39), Serine(31)-

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2007 (1978)

MeSH Record

Previous Indexing

  • Corticotropin (1975-2006)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.935.498w
  2. D06.472w.699w.631.525.600.498w
  3. D12.644w.400w.400.935.498w
  4. D12.644w.548w.365.935.498w
  5. D12.644w.548w.691.525.690.498w
  6. D12.776w.631w.650w.405.935.498w

AMA Style

References

  1. National Library of Medicine. Corticotropin-Like Intermediate Lobe Peptide. Medical Subject Headings (MeSH). 2026. Unique ID D053497. http://id.nlm.nih.gov/mesh/2026/D053497
  2. Corticotropin-Like Intermediate Lobe Peptide. In: Wikipedia. https://en.wikipedia.org/wiki/Corticotropin-like_intermediate_peptide
  3. Corticotropin-Like Intermediate Lobe Peptide. In: Wikidata. https://www.wikidata.org/wiki/Q1753256
  4. Corticotropin-Like Intermediate Lobe Peptide. In: PubChem Compound. CID 16133227. https://pubchem.ncbi.nlm.nih.gov/compound/16133227