Chemicals and Drugs

Pregnane X Receptor

Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • NR1I2
  • Nuclear Receptor Subfamily 1, Group I, Member 2
  • SXR Receptor
  • Steroid X Receptor
  • Steroid and Xenobiotic Receptor

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2019 (1998)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.826w.750w.075w
  2. D12.776w.930w.778w.175w

AMA Style

References

  1. National Library of Medicine. Pregnane X Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D000077297. http://id.nlm.nih.gov/mesh/2026/D000077297
  2. Pregnane X Receptor. In: Wikipedia. https://en.wikipedia.org/wiki/Pregnane_X_receptor
  3. Pregnane X Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q409867