Structured Summary
Abstract
Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.
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Synonyms
7 entry terms
- Pre-B Cell Receptor
- Cell Receptor, Pre-B
- Cell Receptors, Pre-B
- Pre B Cell Receptor
- Pre B Cell Receptors
- Receptor, Pre-B Cell
- Receptors, Pre-B Cell
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19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
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History Note
2008
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Previous Indexing
- Receptors, Antigen, B-Cell (1995-2007)
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References
- National Library of Medicine. Pre-B Cell Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D054420. http://id.nlm.nih.gov/mesh/2026/D054420
- Pre-B Cell Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q58689109