Chemicals and Drugs

Platelet Glycoprotein GPIIb-IIIa Complex

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

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Synonyms

11 entry terms
  • GPIIb-IIIa Receptors
  • Glycoproteins IIb-IIIa
  • Integrin alpha-IIb beta-3
  • Integrin alphaIIbbeta3
  • GPIIb IIIa Receptors
  • Glycoproteins IIb IIIa
  • Integrin alpha IIb beta 3
  • Platelet Glycoprotein GPIIb IIIa Complex
  • Receptors, GPIIb-IIIa
  • alphaIIbbeta3, Integrin
  • beta-3, Integrin alpha-IIb

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995

MeSH Record

Previous Indexing

  • Integrins (1992-1995)
  • Platelet Membrane Glycoproteins (1987-1995)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.785w
  2. D12.776w.395w.550w.625w.785w
  3. D12.776w.543w.550w.625w.785w
  4. D12.776w.543w.750w.705w.408w.460.700w
  5. D12.776w.543w.750w.705w.675w.784w

AMA Style

References

  1. National Library of Medicine. Platelet Glycoprotein GPIIb-IIIa Complex. Medical Subject Headings (MeSH). 2026. Unique ID D019039. http://id.nlm.nih.gov/mesh/2026/D019039
  2. Platelet Glycoprotein GPIIb-IIIa Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Glycoprotein_IIb/IIIa
  3. Platelet Glycoprotein GPIIb-IIIa Complex. In: Wikidata. https://www.wikidata.org/wiki/Q2335787