Chemicals and Drugs

Platelet Activating Factor

A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.

Chemical Identity

Chemical Information

Molecular Formula
C26H54NO7P
Molecular Weight
523.7 g/mol
CAS Registry No.
74389-68-7
IUPAC Name
[(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
InChIKey
HVAUUPRFYPCOCA-AREMUKBSSA-N
SMILES
CCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C
MeSH Unique ID
D010972
Source
PubChem CID 108156

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

14 entry terms
  • 1-Alkyl-2-acetyl-sn-glycerophosphocholine
  • AGEPC
  • Acetyl Glyceryl Ether Phosphorylcholine
  • PAF-Acether
  • Phosphorylcholine, Acetyl Glyceryl Ether
  • Platelet Aggregating Factor
  • Platelet Aggregation Enhancing Factor
  • Platelet-Activating Substance
  • Thrombocyte Aggregating Activity
  • 1 Alkyl 2 acetyl sn glycerophosphocholine
  • Aggregating Factor, Platelet
  • Factor, Platelet Activating
  • PAF Acether
  • Platelet Activating Substance

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1983(1979)

MeSH Record

Previous Indexing

  • Lysophosphatidylcholines (1966-1980)

MeSH Hierarchy

Tree Numbers

  1. D02w.033w.100w.291.211w.500w
  2. D02w.092w.063w.291.211w.500w
  3. D02w.092w.877.883w.333w.710w
  4. D02w.675w.276.232w.710w
  5. D10w.570w.755w.375.760w.400w.985.910w
  6. D23.119.865w
  7. D23.469.050w.600w

AMA Style

References

  1. National Library of Medicine. Platelet Activating Factor. Medical Subject Headings (MeSH). 2026. Unique ID D010972. http://id.nlm.nih.gov/mesh/2026/D010972
  2. Platelet Activating Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Platelet-activating_factor
  3. Platelet Activating Factor. In: Wikidata. https://www.wikidata.org/wiki/Q420577
  4. Platelet Activating Factor. In: PubChem Compound. CID 108156. https://pubchem.ncbi.nlm.nih.gov/compound/108156