Diseases

Parkinson Disease

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • Idiopathic Parkinson Disease
  • Idiopathic Parkinson's Disease
  • Lewy Body Parkinson Disease
  • Lewy Body Parkinson's Disease
  • Paralysis Agitans
  • Parkinson Disease, Idiopathic
  • Parkinson's Disease
  • Parkinson's Disease, Idiopathic
  • Parkinson's Disease, Lewy Body
  • Primary Parkinsonism
  • Parkinsonism, Primary

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

/chem ind = PARKINSON DISEASE, SECONDARY /chem ind

MeSH Record

History Note

1979(1963)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.079w.862w.500w
  2. C10w.228w.662w.600w.400w
  3. C10w.574w.928w.750w

MeSH Record

NLM Classification

WL 359

AMA Style

References

  1. National Library of Medicine. Parkinson Disease. Medical Subject Headings (MeSH). 2026. Unique ID D010300. http://id.nlm.nih.gov/mesh/2026/D010300
  2. Parkinson Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Parkinson%27s_disease
  3. Parkinson Disease. In: Wikidata. https://www.wikidata.org/wiki/Q11085