Structured Summary
Abstract
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
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Classification
Broader headings
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MeSH Record
Synonyms
13 entry terms
- PAR2 Receptor
- Protease-Activated Receptor 2
- Proteinase Activated Receptor 2
- Receptor, PAR-2
- Receptor, Trypsin
- Trypsin Receptor
- Trypsin Receptors
- PAR 2 Receptor
- Protease Activated Receptor 2
- Receptor 2, Protease-Activated
- Receptor, PAR 2
- Receptor, PAR2
- Receptors, Trypsin
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
2004; use RECEPTOR, PAR-2 (NM) 1994-2003; for TRYPSIN RECEPTOR use RECEPTOR, PAR-2 (NM) 1986-2003
MeSH Record
Previous Indexing
- Receptors, Thrombin (1994-2003)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. PAR-2 Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D044464. http://id.nlm.nih.gov/mesh/2026/D044464
- PAR-2 Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24722679