Chemicals and Drugs

Oxyphenbutazone

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)

Chemical Identity

Chemical Information

Molecular Formula
C19H22N2O4
Molecular Weight
342.4 g/mol
CAS Registry No.
7081-38-1
IUPAC Name
4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione;hydrate
InChIKey
CNDQSXOVEQXJOE-UHFFFAOYSA-N
SMILES
CCCCC1C(=O)N(N(C1=O)C2=CC=C(C=C2)O)C3=CC=CC=C3.O
MeSH Unique ID
D010113
Source
PubChem CID 104811

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Hydroxyphenylbutazone
  • Oxyphenylbutazone
  • Diflamil
  • Tanderil

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a non-steroidal anti-inflamm agent

MeSH Record

History Note

64(63)

MeSH Hierarchy

Tree Number

  1. D03w.383.129w.539.850w.777w.700

MeSH Record

NLM Classification

QV 95

AMA Style

References

  1. National Library of Medicine. Oxyphenbutazone. Medical Subject Headings (MeSH). 2026. Unique ID D010113. http://id.nlm.nih.gov/mesh/2026/D010113
  2. Oxyphenbutazone. In: Wikidata. https://www.wikidata.org/wiki/Q27145838
  3. Oxyphenbutazone. In: PubChem Compound. CID 104811. https://pubchem.ncbi.nlm.nih.gov/compound/104811