Chemicals and Drugs

Oncogene Proteins v-erbA

Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

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Synonyms

6 entry terms
  • Oncogene Products v-erbA
  • erbA Oncogene Proteins
  • v-erbA Proteins
  • Oncogene Products v erbA
  • Oncogene Proteins v erbA
  • v erbA Proteins

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

95; was ONCOGENE PROTEIN ERBA (NM) 1987-94

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Previous Indexing

  • Retroviridae Proteins (1987-1989)
  • Retroviridae Proteins, Oncogenic (1990-1994)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.624.664.520.750w.882
  2. D12.776w.964w.700.750w.882
  3. D12.776w.964w.775.750w.882

AMA Style

References

  1. National Library of Medicine. Oncogene Proteins v-erbA. Medical Subject Headings (MeSH). 2026. Unique ID D018774. http://id.nlm.nih.gov/mesh/2026/D018774
  2. Oncogene Proteins v-erbA. In: Wikidata. https://www.wikidata.org/wiki/Q78437912