Chemicals and Drugs

Okadaic Acid

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.

Chemical Identity

Chemical Information

Molecular Formula
C44H68O13
Molecular Weight
805.0 g/mol
CAS Registry No.
78111-17-8
IUPAC Name
(2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acid
InChIKey
QNDVLZJODHBUFM-WFXQOWMNSA-N
SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
MeSH Unique ID
D019319
Source
PubChem CID 446512

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Ocadaic Acid

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97; was OKADAIC ACID (NM) 1982-96

MeSH Record

Previous Indexing

  • Ethers, Cyclic (1982-1996)

MeSH Hierarchy

Tree Numbers

  1. D02w.355w.291.705w
  2. D02w.355w.291.933.875.750w
  3. D02w.540w.576w.625.937.750w
  4. D04w.345w.241.654.937.750w
  5. D04w.345w.674w.625.937.750w
  6. D23.946w.580.710w
  7. D23.946w.580.800.750w

AMA Style

References

  1. National Library of Medicine. Okadaic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D019319. http://id.nlm.nih.gov/mesh/2026/D019319
  2. Okadaic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Okadaic_acid
  3. Okadaic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q414042
  4. Okadaic Acid. In: PubChem Compound. CID 446512. https://pubchem.ncbi.nlm.nih.gov/compound/446512