Chemicals and Drugs

Nod2 Signaling Adaptor Protein

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • CARD15 Protein
  • Caspase Recruitment Domain Protein 15
  • Nucleotide Oligomerization Domain 2 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Carrier Proteins (2001-2004)
  • Intracellular Signaling Peptides and Proteins (2005-2006)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.131.500w
  2. D12.644w.360.024w.313.500w
  3. D12.644w.360.075.358.500w
  4. D12.644w.360.539.500.500w
  5. D12.776w.157w.057w.006.500w
  6. D12.776w.157w.057w.078.500w
  7. D12.776w.476.024w.139.500w
  8. D12.776w.476.024w.391.500w
  9. D12.776w.476.075.358.500w

AMA Style

References

  1. National Library of Medicine. Nod2 Signaling Adaptor Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053473. http://id.nlm.nih.gov/mesh/2026/D053473
  2. Nod2 Signaling Adaptor Protein. In: Wikipedia. https://en.wikipedia.org/wiki/NOD2
  3. Nod2 Signaling Adaptor Protein. In: Wikidata. https://www.wikidata.org/wiki/Q416481