Chemicals and Drugs

Nod1 Signaling Adaptor Protein

A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN. It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN. It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • CARD4 Protein
  • Caspase Recruitment Domain Protein 4
  • Nucleotide Oligomerization Domain 1 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2005-2006)
  • Carrier Proteins (1999-2004)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.131.249
  2. D12.644w.360.024w.313.249
  3. D12.644w.360.075.358.249
  4. D12.644w.360.539.500.249
  5. D12.776w.157w.057w.006.249
  6. D12.776w.157w.057w.078.249
  7. D12.776w.476.024w.139.249
  8. D12.776w.476.024w.391.249
  9. D12.776w.476.075.358.249

AMA Style

References

  1. National Library of Medicine. Nod1 Signaling Adaptor Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053474. http://id.nlm.nih.gov/mesh/2026/D053474
  2. Nod1 Signaling Adaptor Protein. In: Wikidata. https://www.wikidata.org/wiki/Q77039999