Structured Summary
Abstract
An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
8 entry terms
- CYBB Protein
- Chronic Granulomatous Disease Protein
- Cytochrome B-245 Beta Chain
- GP91-PHOX Protein
- NOX2 Protein
- Cytochrome B 245 Beta Chain
- GP91 PHOX Protein
- Oxidase 2, NADPH
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Membrane Glycoproteins (1988-2017)
- NADPH Oxidases (1997-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. NADPH Oxidase 2. Medical Subject Headings (MeSH). 2026. Unique ID D000074662. http://id.nlm.nih.gov/mesh/2026/D000074662
- NADPH Oxidase 2. In: Wikidata. https://www.wikidata.org/wiki/Q4044986