Diseases

Multiple Endocrine Neoplasia Type 1

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

6 entry terms
  • Multiple Endocrine Neoplasia Type I
  • Multiple Endocrine Neoplasms Type 1
  • Neoplasia, Multiple Endocrine Type 1
  • Neoplasms, Multiple Endocrine Type 1
  • Neoplasms, Multiple Endocrine Type I
  • Wermer Syndrome

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent

MeSH Record

History Note

95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94

MeSH Record

Previous Indexing

  • Multiple Endocrine Neoplasia (1972-1994)

MeSH Hierarchy

Tree Numbers

  1. C04w.588.322w.400w.500w
  2. C04w.651.600w.500w
  3. C04w.700w.630w.500w
  4. C16w.320w.700w.630w.500w
  5. C19w.344w.400w.500w

AMA Style

References

  1. National Library of Medicine. Multiple Endocrine Neoplasia Type 1. Medical Subject Headings (MeSH). 2026. Unique ID D018761. http://id.nlm.nih.gov/mesh/2026/D018761
  2. Multiple Endocrine Neoplasia Type 1. In: Wikipedia. https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_1
  3. Multiple Endocrine Neoplasia Type 1. In: Wikidata. https://www.wikidata.org/wiki/Q3347154