Diseases

Multidrug-Resistant Tuberculosis

Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.

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MeSH Record

Synonyms

10 entry terms
  • Tuberculosis, MDR
  • Tuberculosis, Multi-Drug Resistant
  • Tuberculosis, Multidrug-Resistant
  • MDR Tuberculosis
  • Multi-Drug Resistant Tuberculosis
  • Tuberculosis, Multi Drug Resistant
  • Tuberculosis, Multidrug Resistant
  • Tuberculosis, Drug-Resistant
  • Drug-Resistant Tuberculosis
  • Tuberculosis, Drug Resistant

MeSH Record

Aspects Covered

36 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, transmission, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with specific type of tuberculosis + specific antitubercular agents if pertinent; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS is also available

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Drug Resistance, Microbial (1990-1993)
  • Tuberculosis (1990-1993)
  • Tuberculosis, Pulmonary (1990-1993)

MeSH Hierarchy

Tree Number

  1. C01w.150.252w.410.040.552.846w.775w

AMA Style

References

  1. National Library of Medicine. Multidrug-Resistant Tuberculosis. Medical Subject Headings (MeSH). 2026. Unique ID D018088. http://id.nlm.nih.gov/mesh/2026/D018088
  2. Multidrug-Resistant Tuberculosis. In: Wikipedia. https://en.wikipedia.org/wiki/Multidrug-resistant_tuberculosis
  3. Multidrug-Resistant Tuberculosis. In: Wikidata. https://www.wikidata.org/wiki/Q866602