Chemicals and Drugs

Mitogen-Activated Protein Kinase Kinases

A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

26 entry terms
  • MAP Kinase Kinases
  • MAPK Kinase
  • MAPK Kinases
  • MAPKK
  • MAPKKs
  • Map Kinase Kinase
  • Mitogen-Activated Protein Kinase Kinase
  • Kinase Kinase, Map
  • Kinase Kinases, MAP
  • Kinase, MAPK
  • Kinase, Map Kinase
  • Kinases, MAP Kinase
  • Kinases, MAPK
  • Mitogen Activated Protein Kinase Kinase
  • Mitogen Activated Protein Kinase Kinases
  • MAP-ERK Kinase
  • MAPK-ERK Kinase
  • MAPK-ERK Kinases
  • MEK
  • MEKs
  • Kinase, MAP-ERK
  • Kinase, MAPK-ERK
  • Kinases, MAPK-ERK
  • MAP ERK Kinase
  • MAPK ERK Kinase
  • MAPK ERK Kinases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999

MeSH Record

Previous Indexing

  • Protein Kinases (1989-1999)
  • Protein-Serine-Threonine Kinases (1993-1999)
  • Protein-Tyrosine Kinase (1989-1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.565w
  2. D08.811w.913w.696w.620.682w.725w.200w
  3. D12.776w.476.563w.565w
  4. D12.776w.476.568w.200w

AMA Style

References

  1. National Library of Medicine. Mitogen-Activated Protein Kinase Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D020929. http://id.nlm.nih.gov/mesh/2026/D020929
  2. Mitogen-Activated Protein Kinase Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase
  3. Mitogen-Activated Protein Kinase Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q6593810