Structured Summary
Abstract
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
23 entry terms
- JN Kinase Kinase
- JNK Kinase
- JNK-Activating Protein Kinase
- JNKK1 Protein Kinase
- Jun Amino-Terminal Kinase Kinase
- MEK4 Protein Kinase
- Mitogen-Activated Protein Kinase Kinase 4
- SAP Kinase Kinase 1
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAPK-ERK Kinase 1
- SEK1 Protein Kinase
- Stress-Activated Protein Kinase Kinase 1
- JNK Activating Protein Kinase
- Jun Amino Terminal Kinase Kinase
- Kinase, JNKK1 Protein
- Mitogen Activated Protein Kinase Kinase 4
- Protein Kinase, JNK-Activating
- Protein Kinase, JNKK1
- Protein Kinase, MEK4
- Protein Kinase, SEK1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SAPK ERK Kinase 1
- Stress Activated Protein Kinase Kinase 1
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2005(1995)
MeSH Record
Previous Indexing
- Mitogen-Activated Protein Kinases (2000-2004)
- Protein-Serine-Threonine Kinases (1995-1999)
- Protein-Tyrosine Kinase (2000-2004)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. MAP Kinase Kinase 4. Medical Subject Headings (MeSH). 2026. Unique ID D048670. http://id.nlm.nih.gov/mesh/2026/D048670
- MAP Kinase Kinase 4. In: Wikidata. https://www.wikidata.org/wiki/Q21104645