Chemicals and Drugs

Mirtazapine

A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Chemical Identity

Chemical Information

Molecular Formula
C17H19N3
Molecular Weight
265.35 g/mol
CAS Registry No.
85650-52-8
IUPAC Name
5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
InChIKey
RONZAEMNMFQXRA-UHFFFAOYSA-N
SMILES
CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
MeSH Unique ID
D000078785
Source
PubChem CID 4205

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • 6-Azamianserin
  • 6 Azamianserin
  • (N-Methyl-11C)mirtazapine
  • (S)-Mirtazapine
  • Esmirtazapine
  • Norset
  • ORG 3770
  • ORG-3770
  • Org 50081
  • Remergil
  • Remeron
  • Rexer
  • Zispin
  • ORG3770

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1982)

MeSH Hierarchy

Tree Number

  1. D03w.633.300.240.588w

AMA Style

References

  1. National Library of Medicine. Mirtazapine. Medical Subject Headings (MeSH). 2026. Unique ID D000078785. http://id.nlm.nih.gov/mesh/2026/D000078785
  2. Mirtazapine. In: Wikipedia. https://en.wikipedia.org/wiki/Mirtazapine
  3. Mirtazapine. In: Wikidata. https://www.wikidata.org/wiki/Q421930
  4. Mirtazapine. In: PubChem Compound. CID 4205. https://pubchem.ncbi.nlm.nih.gov/compound/4205