Structured Summary
Abstract
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
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Synonyms
3 entry terms
- Methylenetetrahydrofolate Dehydrogenase
- Methylenetetrahydrofolate Dehydrogenase (NADP+)
- Dehydrogenase, Methylenetetrahydrofolate
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
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History Note
2004(1975);
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Previous Indexing
- Oxidoreductases (1973-1974)
- Tetrahydrofolates (1973-1974)
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AMA Style
References
- National Library of Medicine. Methylenetetrahydrofolate Dehydrogenase (NADP). Medical Subject Headings (MeSH). 2026. Unique ID D008754. http://id.nlm.nih.gov/mesh/2026/D008754
- Methylenetetrahydrofolate Dehydrogenase (NADP). In: Wikidata. https://www.wikidata.org/wiki/Q100975544