Structured Summary
Abstract
A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
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Synonyms
6 entry terms
- Formyltetrahydrofolate Synthetase
- Tetrahydrofolate Formylase
- Formate Tetrahydrofolate Ligase
- Formylase, Tetrahydrofolate
- Ligase, Formate-Tetrahydrofolate
- Synthetase, Formyltetrahydrofolate
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
98(75)
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Previous Indexing
- Formic Acids (1969-1974)
- Ligases (1969-1974)
- Tetrahydrofolates (1972-1974)
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AMA Style
References
- National Library of Medicine. Formate-Tetrahydrofolate Ligase. Medical Subject Headings (MeSH). 2026. Unique ID D005574. http://id.nlm.nih.gov/mesh/2026/D005574
- Formate-Tetrahydrofolate Ligase. In: Wikipedia. https://en.wikipedia.org/wiki/Formate%E2%80%93tetrahydrofolate_ligase
- Formate-Tetrahydrofolate Ligase. In: Wikidata. https://www.wikidata.org/wiki/Q24776360