Chemicals and Drugs

Medroxyprogesterone Acetate

A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.

Chemical Identity

Chemical Information

Molecular Formula
C24H34O4
Molecular Weight
386.5 g/mol
CAS Registry No.
71-58-9
IUPAC Name
[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
InChIKey
PSGAAPLEWMOORI-PEINSRQWSA-N
SMILES
C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
MeSH Unique ID
D017258
Source
PubChem CID 6279

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • (6 alpha)-17-(Acetoxy)-6-methylpregn-4-ene-3,20-dione
  • 6-alpha-Methyl-17alpha-hydroxyprogesterone Acetate
  • Depo-Medroxyprogesterone Acetate
  • Medroxyprogesterone 17-Acetate
  • Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)-
  • 6 alpha Methyl 17alpha hydroxyprogesterone Acetate
  • Depo Medroxyprogesterone Acetate
  • Medroxyprogesterone 17 Acetate
  • Curretab
  • Cycrin
  • Depo-Provera
  • Farlutal
  • Gestapuran
  • Medroxyprogesterone 17-Acetate, (6 alpha,17 alpha)-Isomer
  • Medroxyprogesterone 17-Acetate, (6 beta)-Isomer
  • Perlutex
  • Provera
  • Veramix
  • Depo Provera
  • DepoProvera

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2010 (1973)

MeSH Record

Previous Indexing

  • Hydroxyprogesterones (1976-1978)
  • Medroxyprogesterone (1973-1975)
  • Medroxyprogesterone/analogs & derivatives (1978-1992)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.745.745w.654w.829w.395w.700w.500w

AMA Style

References

  1. National Library of Medicine. Medroxyprogesterone Acetate. Medical Subject Headings (MeSH). 2026. Unique ID D017258. http://id.nlm.nih.gov/mesh/2026/D017258
  2. Medroxyprogesterone Acetate. In: Wikipedia. https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate
  3. Medroxyprogesterone Acetate. In: Wikidata. https://www.wikidata.org/wiki/Q2823834
  4. Medroxyprogesterone Acetate. In: PubChem Compound. CID 6279. https://pubchem.ncbi.nlm.nih.gov/compound/6279