Chemicals and Drugs

Mechlorethamine

A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.

Chemical Identity

Chemical Information

Molecular Formula
C5H11Cl2N
Molecular Weight
156.05 g/mol
CAS Registry No.
51-75-2
IUPAC Name
2-chloro-N-(2-chloroethyl)-N-methylethanamine
InChIKey
HAWPXGHAZFHHAD-UHFFFAOYSA-N
SMILES
CN(CCCl)CCCl
MeSH Unique ID
D008466
Source
PubChem CID 4033

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

31 entry terms
  • Bis(2-chloroethyl)methylamine
  • Chlorethazine
  • Chlormethine
  • Methylchlorethamine
  • Mustine
  • Nitrogen Mustard
  • Caryolysine
  • Cloramin
  • Embichin
  • Mechlorethamine Hydrochloride
  • Mechlorethamine Hydrochloride N-Oxide
  • Mechlorethamine N-Oxide
  • Mechlorethamine Oxide
  • Mitomen
  • Mustargen
  • NSC-10107
  • NSC-762
  • Nitrogen Mustard N-Oxide
  • Nitrogranulogen
  • Nitromin
  • Hydrochloride N-Oxide, Mechlorethamine
  • Hydrochloride, Mechlorethamine
  • Mechlorethamine Hydrochloride N Oxide
  • Mechlorethamine N Oxide
  • N-Oxide, Mechlorethamine Hydrochloride
  • N-Oxide, Nitrogen Mustard
  • NSC 10107
  • NSC 762
  • NSC10107
  • NSC762
  • Nitrogen Mustard N Oxide

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

MECHLORETHAMINE OXIDE was heading 1963-79; NITROGEN MUSTARD N-OXIDE was NITROGEN MUSTARD N-OXIDE (NM) 1984-91

MeSH Hierarchy

Tree Number

  1. D02w.455w.526.728w.650w.529w

MeSH Record

NLM Classification

QV 269

AMA Style

References

  1. National Library of Medicine. Mechlorethamine. Medical Subject Headings (MeSH). 2026. Unique ID D008466. http://id.nlm.nih.gov/mesh/2026/D008466
  2. Mechlorethamine. In: Wikipedia. https://en.wikipedia.org/wiki/Chlormethine
  3. Mechlorethamine. In: Wikidata. https://www.wikidata.org/wiki/Q418011
  4. Mechlorethamine. In: PubChem Compound. CID 4033. https://pubchem.ncbi.nlm.nih.gov/compound/4033