Chemicals and Drugs

Mechanistic Target of Rapamycin Complex 1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

MeSH Record

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MeSH Record

Synonyms

6 entry terms
  • TOR Complex 1
  • TORC1
  • Target of Rapamycin Complex 1
  • mTORC1
  • mTORC1 Complex
  • Complex, mTORC1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (2013)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.337w
  2. D08.811w.913w.696w.620.682w.700w.931.500w
  3. D12.776w.476.563w.931.500w

AMA Style

References

  1. National Library of Medicine. Mechanistic Target of Rapamycin Complex 1. Medical Subject Headings (MeSH). 2026. Unique ID D000076222. http://id.nlm.nih.gov/mesh/2026/D000076222
  2. Mechanistic Target of Rapamycin Complex 1. In: Wikipedia. https://en.wikipedia.org/wiki/MTORC1
  3. Mechanistic Target of Rapamycin Complex 1. In: Wikidata. https://www.wikidata.org/wiki/Q14876060