Chemicals and Drugs

LST8 Homolog mTOR Associated Protein

An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • G protein beta Subunit-like Polypeptide
  • GBetaL Protein
  • mLST8 Protein
  • mTOR Associated Protein, LST8 Homolog
  • G protein beta Subunit like Polypeptide

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2013-2017)
  • Proteins (2011-2017)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.337w.250
  2. D08.811w.913w.696w.620.682w.700w.931.500w.250
  3. D12.644w.360.024w.310
  4. D12.776w.157w.057w.073
  5. D12.776w.476.024w.389
  6. D12.776w.476.563w.931.500w.250

AMA Style

References

  1. National Library of Medicine. LST8 Homolog mTOR Associated Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000076242. http://id.nlm.nih.gov/mesh/2026/D000076242
  2. LST8 Homolog mTOR Associated Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21117879