Chemicals and Drugs

Macrophage-Activating Factors

Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.

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Synonyms

2 entry terms
  • Factors, Macrophage-Activating
  • Macrophage Activating Factors

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

91

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Previous Indexing

  • Lymphokines (1976-1990)

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References

  1. National Library of Medicine. Macrophage-Activating Factors. Medical Subject Headings (MeSH). 2026. Unique ID D016215. http://id.nlm.nih.gov/mesh/2026/D016215
  2. Macrophage-Activating Factors. In: Wikipedia. https://en.wikipedia.org/wiki/Macrophage-activating_factor
  3. Macrophage-Activating Factors. In: Wikidata. https://www.wikidata.org/wiki/Q6725501