Chemicals and Drugs

Interferon-gamma

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • Interferon Type II
  • Interferon, Immune
  • Interferon, gamma
  • Type II Interferon
  • gamma-Interferon
  • Immune Interferon
  • Interferon, Type II

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2009(1983); INTERFERON-GAMMA was INTERFERON, GAMMA 1983-1990

MeSH Record

Previous Indexing

  • Interferons (1966-1982)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.440w.893w
  2. D12.644w.276.374w.480w.615w.350w
  3. D12.776w.467.374w.440w.893w
  4. D12.776w.467.374w.480w.615w.350w
  5. D23.529.374w.440w.893w
  6. D23.529.374w.480w.615w.350w

AMA Style

References

  1. National Library of Medicine. Interferon-gamma. Medical Subject Headings (MeSH). 2026. Unique ID D007371. http://id.nlm.nih.gov/mesh/2026/D007371
  2. Interferon-gamma. In: Wikipedia. https://en.wikipedia.org/wiki/Interferon_gamma
  3. Interferon-gamma. In: Wikidata. https://www.wikidata.org/wiki/Q24741149