Chemicals and Drugs

MAP Kinase Kinase Kinases

Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

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Synonyms

26 entry terms
  • Kinases, MAP Kinase Kinase
  • MAP Kinase Kinase Kinase
  • MAP3 Kinase
  • MAP3 Kinases
  • MAPKKK
  • MAPKKKs
  • Mitogen-Activated Protein Kinase Kinase Kinase
  • Mitogen-Activated Protein Kinase Kinase Kinases
  • Kinase, MAP3
  • Kinases, MAP3
  • Mitogen Activated Protein Kinase Kinase Kinase
  • Mitogen Activated Protein Kinase Kinase Kinases
  • MAPK-ERK Kinase Kinase
  • MAPK-ERK Kinase Kinases
  • MEK Kinase
  • MEK Kinases
  • MEKK
  • MEKKs
  • Kinase Kinase, MAPK-ERK
  • Kinase Kinases, MAPK-ERK
  • Kinase, MAPK-ERK Kinase
  • Kinase, MEK
  • Kinases, MAPK-ERK Kinase
  • Kinases, MEK
  • MAPK ERK Kinase Kinase
  • MAPK ERK Kinase Kinases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; use MAP KINASE KINASE KINASE 1992-1999

MeSH Record

Previous Indexing

  • Protein Kinases (1989-1999)
  • Protein-Serine-Threonine Kinases (1993-1999)
  • Protein-Tyrosine Kinase (1989-1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.559w
  2. D12.776w.476.563w.554w

AMA Style

References

  1. National Library of Medicine. MAP Kinase Kinase Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D020930. http://id.nlm.nih.gov/mesh/2026/D020930
  2. MAP Kinase Kinase Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/MAP_kinase_kinase_kinase
  3. MAP Kinase Kinase Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q6714442