Chemicals and Drugs

Low Density Lipoprotein Receptor-Related Protein-2

An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

16 entry terms
  • Antigen GP 330, Nephritis
  • GP330 Antigen
  • Glycoprotein 330
  • Heyman's Nephritis Antigen GP330
  • Heymann Nephritis Antigen GP330
  • LDL-Receptor Related Protein 2
  • LRP-2 Receptor
  • Low-Density Lipoprotein Receptor-Related Protein-2
  • Megalin
  • Nephritis Antigen (GP330)
  • Renal Glycoprotein GP330
  • GP330, Renal Glycoprotein
  • Glycoprotein GP330, Renal
  • LDL Receptor Related Protein 2
  • LRP 2 Receptor
  • Low Density Lipoprotein Receptor Related Protein 2

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

Indexing Annotation

note entry term Heymann Nephritis Antigen GP330: HEYMANN NEPHRITIS ANTIGENIC COMPLEX is also available

MeSH Record

History Note

2012(2002)

MeSH Record

Previous Indexing

  • Antigens, Surface (1984-1988)
  • Membrane Glycoproteins (1989-2001)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.526.200w
  2. D12.776w.543w.750w.710.450w.500.200w
  3. D23.050w.422.500.500w

AMA Style

References

  1. National Library of Medicine. Low Density Lipoprotein Receptor-Related Protein-2. Medical Subject Headings (MeSH). 2026. Unique ID D026561. http://id.nlm.nih.gov/mesh/2026/D026561
  2. Low Density Lipoprotein Receptor-Related Protein-2. In: Wikipedia. https://en.wikipedia.org/wiki/LRP2
  3. Low Density Lipoprotein Receptor-Related Protein-2. In: Wikidata. https://www.wikidata.org/wiki/Q21202030