Chemicals and Drugs

LDL Receptors

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

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Synonyms

10 entry terms
  • LDL Receptor
  • LDL Receptors, Lipoprotein
  • Lipoprotein LDL Receptors
  • Low Density Lipoprotein Receptor
  • Low Density Lipoprotein Receptors
  • Receptors, LDL
  • Receptors, Lipoprotein, LDL
  • Receptors, Low Density Lipoprotein
  • Receptor, LDL
  • Receptors, Lipoprotein LDL

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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History Note

85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92

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Previous Indexing

  • Lipoproteins, LDL (1972-1984)
  • Receptors, Endogenous Substances (1973-1984)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.710.450w

MeSH Record

NLM Classification

QU 95

AMA Style

References

  1. National Library of Medicine. LDL Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D011973. http://id.nlm.nih.gov/mesh/2026/D011973
  2. LDL Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/LDL_receptor
  3. LDL Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q425649