Structured Summary
Abstract
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- Cystatins, Kininogen
- Prekinins
- Prokinins
- Kininogen Cystatins
- Kininogen
- T-Kininogen
- Thiostatin
- T Kininogen
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
cysteine proteinase inhib; /drug eff /physiol permitted
MeSH Record
History Note
74(72)
MeSH Record
Previous Indexing
- Kinins (1966-1971)
- Proteins (1966-1971)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Kininogens. Medical Subject Headings (MeSH). 2026. Unique ID D007704. http://id.nlm.nih.gov/mesh/2026/D007704
- Kininogens. In: Wikipedia. https://en.wikipedia.org/wiki/Kininogen
- Kininogens. In: Wikidata. https://www.wikidata.org/wiki/Q6413860