Chemicals and Drugs

High-Molecular-Weight Kininogen

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Fitzgerald Factor
  • HMWK
  • High Molecular Weight Kininogen
  • High Molecular Weight Kininogens
  • High-Molecular-Weight Kininogens
  • Kininogen, High-Molecular-Weight
  • Kininogens, High Molecular Weight
  • Kininogen, High Molecular Weight
  • Kininogens, High-Molecular-Weight

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use KININOGENS 1989-97

MeSH Record

Previous Indexing

  • Kininogens (1974-1997)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.812w.654w.350w
  2. D12.776w.124w.125.635w.480w
  3. D12.776w.467.812w.654w.350w
  4. D12.776w.811w.420w.350w
  5. D23.119.630w.480w
  6. D23.469.050w.375w.425w.350w
  7. D23.529.812w.654w.350w

AMA Style

References

  1. National Library of Medicine. High-Molecular-Weight Kininogen. Medical Subject Headings (MeSH). 2026. Unique ID D019679. http://id.nlm.nih.gov/mesh/2026/D019679
  2. High-Molecular-Weight Kininogen. In: Wikipedia. https://en.wikipedia.org/wiki/High-molecular-weight_kininogen
  3. High-Molecular-Weight Kininogen. In: Wikidata. https://www.wikidata.org/wiki/Q24721273