Diseases

Hyperkalemic Periodic Paralysis

An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)

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MeSH Record

Synonyms

16 entry terms
  • Adynamia Episodica Hereditaria
  • Adynamia Episodica Hereditaria with or without Myotonia
  • Familial Hyperkalemic Periodic Paralysis
  • Gamstorp Disease
  • Gamstorp Episodic Adynamy
  • HyperKPP
  • HyperPP
  • Hyperkalemic Periodic Paralysis, Familial
  • Myotonic Periodic Paralysis
  • Paralysis, Hyperkalemic Periodic
  • Paralysis, Periodic, Hyperkalemic, Familial
  • Primary Hyperkalemic Periodic Paralysis
  • Sodium Channel Muscle Disease
  • Disease, Gamstorp
  • Hyperkalemic Periodic Paralysis Type 2
  • Hyperkaliemic Periodic Paralysis Type 2

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • Paralyses, Familial Periodic (1966-1999)

MeSH Hierarchy

Tree Numbers

  1. C05w.651w.701w.600w
  2. C10w.668w.491w.650w.600w
  3. C16w.320w.565w.618w.711w.600w
  4. C18.452w.648w.618w.711w.600w

AMA Style

References

  1. National Library of Medicine. Hyperkalemic Periodic Paralysis. Medical Subject Headings (MeSH). 2026. Unique ID D020513. http://id.nlm.nih.gov/mesh/2026/D020513
  2. Hyperkalemic Periodic Paralysis. In: Wikipedia. https://en.wikipedia.org/wiki/Hyperkalemic_periodic_paralysis
  3. Hyperkalemic Periodic Paralysis. In: Wikidata. https://www.wikidata.org/wiki/Q3269843