Chemicals and Drugs

Glycyrrhetinic Acid

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

Chemical Identity

Chemical Information

Molecular Formula
C30H46O4
Molecular Weight
470.7 g/mol
CAS Registry No.
471-53-4
IUPAC Name
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
InChIKey
MPDGHEJMBKOTSU-YKLVYJNSSA-N
SMILES
C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
MeSH Unique ID
D006034
Source
PubChem CID 10114

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • Enoxolone
  • Glyciram
  • Glycyram
  • Glycyrrhetic Acid
  • Jintan
  • Rhetinic Acid
  • Uralenic Acid
  • Acid, Glycyrrhetic
  • Acid, Glycyrrhetinic
  • Acid, Rhetinic
  • Acid, Uralenic
  • Arthrodont
  • Po 12
  • 12, Po

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

79; was ENOXOLONE see under TRITERPENES 1977-78

MeSH Record

Previous Indexing

  • Glycyrrhiza (1966-1976)
  • Triterpenes (1974-1976)

MeSH Hierarchy

Tree Number

  1. D02w.455w.849w.919w.530.444w

AMA Style

References

  1. National Library of Medicine. Glycyrrhetinic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D006034. http://id.nlm.nih.gov/mesh/2026/D006034
  2. Glycyrrhetinic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Enoxolone
  3. Glycyrrhetinic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q5948038
  4. Glycyrrhetinic Acid. In: PubChem Compound. CID 10114. https://pubchem.ncbi.nlm.nih.gov/compound/10114