Diseases

Glioblastoma

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

10 entry terms
  • Astrocytoma, Grade IV
  • Astrocytomas, Grade IV
  • Glioblastomas
  • Grade IV Astrocytoma
  • Grade IV Astrocytomas
  • Giant Cell Glioblastoma
  • Glioblastoma Multiforme
  • Giant Cell Glioblastomas
  • Glioblastoma, Giant Cell
  • Glioblastomas, Giant Cell

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coord IM with probably precoord CNS/neopl term + site (IM); for GLIOBLASTOMA WITH SARCOMATOUS COMPONENT see GLIOSARCOMA; for GLIOBLASTOMA, RETINAL see RETINOBLASTOMA

MeSH Record

History Note

94; was GLIOBLASTOMA MULTIFORME 1963-93; GLIOBLASTOMA was see ASTROCYTOMA 1993

MeSH Hierarchy

Tree Numbers

  1. C04w.557.465.625w.600.380w.080w.335w
  2. C04w.557.470.670.380w.080w.335w
  3. C04w.557.580.625w.600.380w.080w.335w

AMA Style

References

  1. National Library of Medicine. Glioblastoma. Medical Subject Headings (MeSH). 2026. Unique ID D005909. http://id.nlm.nih.gov/mesh/2026/D005909
  2. Glioblastoma. In: Wikipedia. https://en.wikipedia.org/wiki/Glioblastoma
  3. Glioblastoma. In: Wikidata. https://www.wikidata.org/wiki/Q282142