Diseases

Gangliosidoses

A group of autosomal recessive lysosomal storage disorders marked by the accumulation of GANGLIOSIDES. They are caused by impaired enzymes or defective cofactors required for normal ganglioside degradation in the LYSOSOMES. Gangliosidoses are classified by the specific ganglioside accumulated in the defective degradation pathway.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of autosomal recessive lysosomal storage disorders marked by the accumulation of GANGLIOSIDES. They are caused by impaired enzymes or defective cofactors required for normal ganglioside degradation in the LYSOSOMES. Gangliosidoses are classified by the specific ganglioside accumulated in the defective degradation pathway.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

9 entry terms
  • Ganglioside Storage Diseases
  • Ganglioside Storage Disorders
  • Gangliosidosis
  • Ganglioside Storage Disease
  • Ganglioside Storage Disorder
  • Storage Disease, Ganglioside
  • Storage Diseases, Ganglioside
  • Storage Disorder, Ganglioside
  • Storage Disorders, Ganglioside

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate IM with specific ganglioside (IM) but GANGLIOSIDOSIS, GM1 and GANGLIOSIDOSES, GM2 are available

MeSH Record

History Note

1992(1976)

MeSH Record

Previous Indexing

  • Gangliosides (1966-1975)
  • Lipoidosis (1966-1975)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.163.100.435.825w.300w
  2. C16w.320w.565w.189.435.825w.300w
  3. C16w.320w.565w.398w.641w.803w.350w
  4. C16w.320w.565w.595w.554.825w.300w
  5. C18.452w.132.100.435.825w.300w
  6. C18.452w.584w.563w.641w.803w.350w
  7. C18.452w.648w.189.435.825w.300w
  8. C18.452w.648w.398w.641w.803w.350w
  9. C18.452w.648w.595w.554.825w.300w

AMA Style

References

  1. National Library of Medicine. Gangliosidoses. Medical Subject Headings (MeSH). 2026. Unique ID D005733. http://id.nlm.nih.gov/mesh/2026/D005733
  2. Gangliosidoses. In: Wikipedia. https://en.wikipedia.org/wiki/Gangliosidosis
  3. Gangliosidoses. In: Wikidata. https://www.wikidata.org/wiki/Q1493513