Diseases

GM2 Gangliosidoses

A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.

MeSH Record

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MeSH Record

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MeSH Record

Synonyms

8 entry terms
  • G(M2) Gangliosidoses
  • GM2 Gangliosidosis
  • Gangliosidoses GM2
  • Gangliosidoses, GM2
  • GM2 Gangliosidose
  • GM2, Gangliosidoses
  • Gangliosidose, GM2
  • Gangliosidosis, GM2

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2007 (2000)

MeSH Record

Previous Indexing

  • Sandhoff Disease (1966-1999)
  • Tay-Sachs Disease (1966-1999)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.163.100.435.825w.300w.300w
  2. C16w.320w.565w.189.435.825w.300w.300w
  3. C16w.320w.565w.398w.641w.803w.350w.300w
  4. C16w.320w.565w.595w.554.825w.300w.300w
  5. C18.452w.132.100.435.825w.300w.300w
  6. C18.452w.584w.563w.641w.803w.350w.300w
  7. C18.452w.648w.189.435.825w.300w.300w
  8. C18.452w.648w.398w.641w.803w.350w.300w
  9. C18.452w.648w.595w.554.825w.300w.300w

AMA Style

References

  1. National Library of Medicine. GM2 Gangliosidoses. Medical Subject Headings (MeSH). 2026. Unique ID D020143. http://id.nlm.nih.gov/mesh/2026/D020143
  2. GM2 Gangliosidoses. In: Wikipedia. https://en.wikipedia.org/wiki/GM2_gangliosidoses
  3. GM2 Gangliosidoses. In: Wikidata. https://www.wikidata.org/wiki/Q5513691