Chemicals and Drugs

Fibrillin-1

A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling the availability and concentration of TGF-BETA and BONE MORPHOGENETIC PROTEINS. Mutations in the FBN1 gene are associated with MARFAN SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling the availability and concentration of TGF-BETA and BONE MORPHOGENETIC PROTEINS. Mutations in the FBN1 gene are associated with MARFAN SYNDROME.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Fibrillin 1
  • Asprosin
  • Profibrillin 1
  • Profibrillin-1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017; use FIBRILLIN 1985-2016

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.042w.375
  2. D09w.400w.430w.800w.500
  3. D12.776w.395w.341w.500
  4. D12.776w.860w.300.400w.500

AMA Style

References

  1. National Library of Medicine. Fibrillin-1. Medical Subject Headings (MeSH). 2026. Unique ID D000071838. http://id.nlm.nih.gov/mesh/2026/D000071838
  2. Fibrillin-1. In: Wikidata. https://www.wikidata.org/wiki/Q21118138