Structured Summary
Abstract
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
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Classification
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Synonyms
13 entry terms
- Blood Coagulation Factor VIII, Activated
- Coagulation Factor VIIIa
- Factor 8A
- Factor Eight A
- Factor VIII, Activated
- Factor VIII, Thrombin-Activated
- Activated Factor VIII
- Factor VIII, Thrombin Activated
- Factor VIIIa, Coagulation
- Thrombin-Activated Factor VIII
- Factor VIIIa Heavy Chain, 200 kDa Isoform
- Factor VIIIa Heavy Chain, 92 kDa Isoform
- Factor VIIIa Light Chain
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
90
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Previous Indexing
- Factor VIII (1981-1989)
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AMA Style
References
- National Library of Medicine. Factor VIIIa. Medical Subject Headings (MeSH). 2026. Unique ID D015944. http://id.nlm.nih.gov/mesh/2026/D015944
- Factor VIIIa. In: Wikidata. https://www.wikidata.org/wiki/Q50259302