Chemicals and Drugs

Erythrocyte Anion Exchange Protein 1

A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

31 entry terms
  • AE1 Anion Exchanger
  • AE1 Chloride-Bicarbonate Exchanger
  • AE1 Cl- HCO3- Exchanger
  • AE1 Gene Product
  • Anion Exchange Protein 1, Erythrocyte
  • Anion Exchanger 1
  • Anion Transport Protein, Erythrocyte
  • Antigens, CD233
  • Band 3 Anion Transport Protein
  • Band 3 Protein
  • Band III Protein
  • CD233 Antigen
  • CD233 Antigens
  • Capnophorin
  • EPB3 Protein
  • Erythrocyte Anion Exchanger
  • Erythrocyte Anion Transport Protein
  • Erythrocyte Membrane Anion Transport Protein
  • Erythrocyte Membrane Band 3 Protein
  • Erythrocyte Membrane Protein Band 3, Diego Blood Group
  • Protein Band 3
  • SLC4A1 Protein
  • Solute Carrier Family 4 Member 1
  • Solute Carrier Family 4, Anion Exchanger, Member 1
  • AE1 Chloride Bicarbonate Exchanger
  • AE1 Cl HCO3 Exchanger
  • Anion Exchanger, Erythrocyte
  • Antigen, CD233
  • Chloride-Bicarbonate Exchanger, AE1
  • Exchanger 1, Anion
  • Protein, EPB3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2002(1984); for AE1 ANION EXCHANGER, AE1 CHLORIDE-BICARBONATE EXCHANGER, AE1 Cl- HCO3- EXCHANGER & AE1 GENE PRODUCT use CHLORIDE-BICARBONATE ANTIPORTERS (NM) 1998-2001

MeSH Record

Previous Indexing

  • Blood Proteins (1966-1983)
  • Membrane Proteins (1977-1983)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.450w.162w.193w.500
  2. D12.776w.157w.530w.450w.437w.249w.500
  3. D12.776w.157w.530w.937w.656w.249w.500
  4. D12.776w.543w.550w.190w.276w.500
  5. D12.776w.543w.550w.779w.249w.500
  6. D12.776w.543w.585w.450w.162w.193w.500
  7. D12.776w.543w.585w.450w.437w.249w.500
  8. D12.776w.543w.585w.937w.776w.249w.500

AMA Style

References

  1. National Library of Medicine. Erythrocyte Anion Exchange Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D001457. http://id.nlm.nih.gov/mesh/2026/D001457
  2. Erythrocyte Anion Exchange Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q78446631