Chemicals and Drugs

SLC4A Proteins

Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).

MeSH Record

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MeSH Record

Synonyms

8 entry terms
  • Proteins, SLC4A
  • Bicarbonate Transporter-Related Protein 1
  • SLC4A11 Protein
  • Sodium Borate Cotransporter 1
  • Solute Carrier Family 4 Member 11
  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 11
  • Bicarbonate Transporter Related Protein 1
  • Protein, SLC4A11

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

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Tree Numbers

  1. D12.776w.157w.530w.450w.437w
  2. D12.776w.157w.530w.937w.656w
  3. D12.776w.543w.550w.779w
  4. D12.776w.543w.585w.450w.437w
  5. D12.776w.543w.585w.937w.776w

AMA Style

References

  1. National Library of Medicine. SLC4A Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D064606. http://id.nlm.nih.gov/mesh/2026/D064606
  2. SLC4A Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Anion_exchanger_family
  3. SLC4A Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q24787711