Chemicals and Drugs

Dystrophin

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

a muscle protein: see MeSH definition for relation to musc dystrophy; /biosyn /drug eff /physiol /ultrastruct permitted

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Muscle Proteins (1988-1990)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.210.500.250w
  2. D12.776w.220.250w
  3. D12.776w.543w.250w

AMA Style

References

  1. National Library of Medicine. Dystrophin. Medical Subject Headings (MeSH). 2026. Unique ID D016189. http://id.nlm.nih.gov/mesh/2026/D016189
  2. Dystrophin. In: Wikipedia. https://en.wikipedia.org/wiki/Dystrophin
  3. Dystrophin. In: Wikidata. https://www.wikidata.org/wiki/Q412285