Diseases

Duchenne Muscular Dystrophy

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

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MeSH Record

Synonyms

28 entry terms
  • Cardiomyopathy, Dilated, 3B
  • Cardiomyopathy, Dilated, X-Linked
  • Childhood Muscular Dystrophy, Pseudohypertrophic
  • Childhood Pseudohypertrophic Muscular Dystrophy
  • Duchenne-Type Progressive Muscular Dystrophy
  • Muscular Dystrophy, Childhood, Pseudohypertrophic
  • Muscular Dystrophy, Duchenne
  • Muscular Dystrophy, Duchenne Type
  • Muscular Dystrophy, Pseudohypertrophic
  • Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
  • Muscular Dystrophy, Pseudohypertrophic, Childhood
  • Progressive Muscular Dystrophy, Duchenne Type
  • Pseudohypertrophic Childhood Muscular Dystrophy
  • Pseudohypertrophic Muscular Dystrophy, Childhood
  • Duchenne Type Progressive Muscular Dystrophy
  • Pseudohypertrophic Muscular Dystrophy
  • Becker Muscular Dystrophy
  • Becker's Muscular Dystrophy
  • Duchenne and Becker Muscular Dystrophy
  • Duchenne-Becker Muscular Dystrophy
  • Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type
  • Muscular Dystrophy, Becker
  • Muscular Dystrophy, Becker Type
  • Muscular Dystrophy, Duchenne and Becker Types
  • Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type
  • Duchenne Becker Muscular Dystrophy
  • Muscular Dystrophy, Becker's
  • Muscular Dystrophy, Duchenne-Becker

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, virology.

MeSH Record

History Note

2000; use MUSCULAR DYSTROPHIES 1980-1999; for MUSCULAR DYSTROPHY, BECKER & BECKER MUSCULAR DYSTROPHY use MUSCULAR DYSTROPHIES 1991-1999

MeSH Record

Previous Indexing

  • Muscular Dystrophies (1966-1999)

MeSH Hierarchy

Tree Numbers

  1. C05w.651w.534.500w.300w
  2. C10w.668w.491w.175.500w.300w
  3. C16w.320w.322.562w
  4. C16w.320w.577w.300w

AMA Style

References

  1. National Library of Medicine. Duchenne Muscular Dystrophy. Medical Subject Headings (MeSH). 2026. Unique ID D020388. http://id.nlm.nih.gov/mesh/2026/D020388
  2. Duchenne Muscular Dystrophy. In: Wikipedia. https://en.wikipedia.org/wiki/Duchenne_muscular_dystrophy
  3. Duchenne Muscular Dystrophy. In: Wikidata. https://www.wikidata.org/wiki/Q1648484