Structured Summary
Abstract
NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver, trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They are critical for the activity of THYROID PEROXIDASE and play a role in the production of thyroid hormones; they may also have antimicrobial activity through the generation of REACTIVE OXYGEN SPECIES.
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Classification
Broader headings
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Synonyms
14 entry terms
- Dual Oxidase
- Duox Proteins
- Oxidase, Dual
- Oxidases, Dual
- Proteins, Duox
- DUOX1
- DUOX2
- Dual Oxidase 1
- Dual Oxidase 2
- NADPH Thyroid Oxidase 2
- Thyroid Oxidase 2
- Oxidase 1, Dual
- Oxidase 2, Dual
- Oxidase 2, Thyroid
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- NADPH Oxidases (2001-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Dual Oxidases. Medical Subject Headings (MeSH). 2026. Unique ID D000074623. http://id.nlm.nih.gov/mesh/2026/D000074623
- Dual Oxidases. In: Wikidata. https://www.wikidata.org/wiki/Q73970232