Structured Summary
Abstract
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
MeSH Record
Classification
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MeSH Record
Synonyms
16 entry terms
- DNA Endonuclease
- DNAase I
- DNase I
- Pancreatic DNase
- Thymonuclease
- DNase, Pancreatic
- Endonuclease, DNA
- DNA Nicking Enzyme
- Dornavac
- Endonuclease I
- Nickase
- Streptodornase
- T4-Endonuclease II
- T7-Endonuclease I
- T4 Endonuclease II
- T7 Endonuclease I
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
do not confuse entry term STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE
MeSH Record
History Note
85; STREPTODORNASE was see DEOXYRIBONUCLEASES 1966-93
MeSH Record
Previous Indexing
- Deoxyribonucleases (1966-1982)
- Endodeoxyribonucleases (1983-1984)
- Endonucleases (1973-1982)
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AMA Style
References
- National Library of Medicine. Deoxyribonuclease I. Medical Subject Headings (MeSH). 2026. Unique ID D003850. http://id.nlm.nih.gov/mesh/2026/D003850
- Deoxyribonuclease I. In: Wikidata. https://www.wikidata.org/wiki/Q24772449