Chemicals and Drugs

DNA Ligases

Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).

MeSH Record

Classification

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MeSH Record

Synonyms

12 entry terms
  • DNA Joinases
  • DNA Ligase
  • Polydeoxyribonucleotide Ligases
  • Polydeoxyribonucleotide Synthetases
  • Joinases, DNA
  • Ligase, DNA
  • Ligases, DNA
  • Ligases, Polydeoxyribonucleotide
  • Synthetases, Polydeoxyribonucleotide
  • T4 DNA Ligase
  • DNA Ligase, T4
  • Ligase, T4 DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse entry term POLYDEOXYRIBONUCLEOTIDE SYNTHETASES with entry term POLYRIBONUCLEOTIDE SYNTHETASE

MeSH Record

History Note

98(77); for DNA LIGASES use POLYNUCLEOTIDE SYNTHETASES 1973-76

MeSH Record

Previous Indexing

  • Polynucleotide Synthetases (1974-1977)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. DNA Ligases. Medical Subject Headings (MeSH). 2026. Unique ID D011088. http://id.nlm.nih.gov/mesh/2026/D011088
  2. DNA Ligases. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_ligase
  3. DNA Ligases. In: Wikidata. https://www.wikidata.org/wiki/Q408483