Chemicals and Drugs

DNA Ligase ATP

ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

25 entry terms
  • ATP-Dependent DNA Ligase
  • DNA Ligases, ATP-Dependent
  • Polydeoxyribonucleotide Synthase ATP
  • ATP Dependent DNA Ligase
  • ATP, DNA Ligase
  • ATP, Polydeoxyribonucleotide Synthase
  • ATP-Dependent DNA Ligases
  • DNA Ligase, ATP-Dependent
  • DNA Ligases, ATP Dependent
  • Ligase ATP, DNA
  • Ligase, ATP-Dependent DNA
  • Ligases, ATP-Dependent DNA
  • Synthase ATP, Polydeoxyribonucleotide
  • DNA Ligase I
  • DNA Ligase II
  • DNA Ligase III
  • DNA Ligase IIIalpha
  • DNA Ligase IV
  • LIGIIIalpha Protein
  • IIIalpha, DNA Ligase
  • Ligase I, DNA
  • Ligase II, DNA
  • Ligase III, DNA
  • Ligase IIIalpha, DNA
  • Ligase IV, DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1986)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.074.500w.500
  2. D08.811w.464w.754.600w.500

AMA Style

References

  1. National Library of Medicine. DNA Ligase ATP. Medical Subject Headings (MeSH). 2026. Unique ID D000072481. http://id.nlm.nih.gov/mesh/2026/D000072481
  2. DNA Ligase ATP. In: Wikidata. https://www.wikidata.org/wiki/Q24739402