Phenomena and Processes

DNA Damage Tolerance

Strategies that cells use to continue DNA replication when replicative DNA polymerases stall at DNA damage-blocked replication forks. These DNA damage tolerant replication mechanisms bypass the DNA DAMAGE, which may be repaired subsequently by various DNA REPAIR mechanisms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Strategies that cells use to continue DNA replication when replicative DNA polymerases stall at DNA damage-blocked replication forks. These DNA damage tolerant replication mechanisms bypass the DNA DAMAGE, which may be repaired subsequently by various DNA REPAIR mechanisms.

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Synonyms

14 entry terms
  • DNA Damage Bypass Pathways
  • DNA Damage Tolerance Pathways
  • DNA Damage Tolerant Replication
  • Post Replication Repair
  • Post-Replication Repair
  • Postreplication Repair
  • Postreplicative Repair
  • Post-Replication Repairs
  • Postreplicative Template Switching
  • Replication Fork Reversal
  • Replication Template Switching
  • Fork Reversal, Replication
  • Template Switching, Postreplicative
  • Template Switching, Replication

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2024

MeSH Hierarchy

Tree Numbers

  1. G02.111.225w.380w
  2. G05.226w.380w

AMA Style

References

  1. National Library of Medicine. DNA Damage Tolerance. Medical Subject Headings (MeSH). 2026. Unique ID D000097122. http://id.nlm.nih.gov/mesh/2026/D000097122
  2. DNA Damage Tolerance. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_damage_tolerance
  3. DNA Damage Tolerance. In: Wikidata. https://www.wikidata.org/wiki/Q124358839