Chemicals and Drugs

Cytochrome P-450 CYP3A

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

26 entry terms
  • CYP3A
  • Cytochrome P-450IIIA
  • Cytochrome P450 3A
  • Erythromycin N-Demethylase
  • Cytochrome P 450 CYP3A
  • Cytochrome P 450IIIA
  • Erythromycin N Demethylase
  • N-Demethylase, Erythromycin
  • P-450 CYP3A, Cytochrome
  • P-450IIIA, Cytochrome
  • P450 3A, Cytochrome
  • CYP3A4
  • CYP3A5
  • Cytochrome P-450 CYP3A4
  • Cytochrome P-450 CYP3A5
  • Cytochrome P450 3A4
  • Cytochrome P450 3A5
  • Taurochenodeoxycholate 6-alpha-Monooxygenase
  • 3A5, Cytochrome P450
  • 6-alpha-Monooxygenase, Taurochenodeoxycholate
  • Cytochrome P 450 CYP3A4
  • Cytochrome P 450 CYP3A5
  • P-450 CYP3A4, Cytochrome
  • P-450 CYP3A5, Cytochrome
  • P450 3A5, Cytochrome
  • Taurochenodeoxycholate 6 alpha Monooxygenase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1980)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.860.500
  2. D08.811w.682w.662.582.353
  3. D08.811w.682w.690w.708.170w.495.500
  4. D12.776w.422w.220w.453w.860.500

AMA Style

References

  1. National Library of Medicine. Cytochrome P-450 CYP3A. Medical Subject Headings (MeSH). 2026. Unique ID D051544. http://id.nlm.nih.gov/mesh/2026/D051544
  2. Cytochrome P-450 CYP3A. In: Wikidata. https://www.wikidata.org/wiki/Q76943866