Chemicals and Drugs

Cytochrome P-450 CYP2E1

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

17 entry terms
  • 4-Nitrophenol-2-Hydroxylase
  • CYP 2E1
  • CYP IIE1
  • CYP2E1
  • CYPIIE1
  • Cytochrome P-450 (ALC)
  • Cytochrome P-450 IIE1
  • Cytochrome P-450-J
  • Cytochrome P450 2E1
  • Dimethylnitrosamine N-Demethylase
  • N-Nitrosodimethylamine Demethylase
  • 4 Nitrophenol 2 Hydroxylase
  • Cytochrome P 450 CYP2E1
  • Cytochrome P 450 IIE1
  • Cytochrome P 450 J
  • Dimethylnitrosamine N Demethylase
  • N Nitrosodimethylamine Demethylase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with other cytochrome P-450 CYP's

MeSH Record

History Note

97; was DIMETHYLNITROSAMIME N-DEMETHYLASE (NM) 1972-96 & was 4-NITROPHENOL-2-HYDROXYLASE (NM) 1984-96

MeSH Record

Previous Indexing

  • Cytochrome P-450 (1975-1996)
  • Hydroxylases (1984-1996)
  • Nitrosamines (1972-1976)
  • Oxidoreductases (1972-1974)
  • Oxidoreductases, N-Demethylating (1975-1996)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.491.375
  2. D08.811w.682w.662.582.338
  3. D08.811w.682w.690w.708.170w.450.375
  4. D12.776w.422w.220w.453w.491.375

AMA Style

References

  1. National Library of Medicine. Cytochrome P-450 CYP2E1. Medical Subject Headings (MeSH). 2026. Unique ID D019392. http://id.nlm.nih.gov/mesh/2026/D019392
  2. Cytochrome P-450 CYP2E1. In: Wikidata. https://www.wikidata.org/wiki/Q4210020