Chemicals and Drugs

Cytochrome P-450 CYP11B2

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

19 entry terms
  • Aldosterone Synthase
  • Aldosterone Synthase Cytochrome P-450
  • Aldosynthase
  • CYP 11B2
  • CYP11B2
  • Cytochrome P-450c11AS
  • Cytochrome P450 11B2
  • Cytochrome P450Aldo
  • P450c11AS
  • Steroid 18-Hydroxylase
  • Cytochrome P 450 CYP11B2
  • Cytochrome P 450c11AS
  • Steroid 18 Hydroxylase
  • Corticosterone 18-hydroxylase
  • Corticosterone 18-monooxygenase
  • 18-hydroxylase, Corticosterone
  • 18-monooxygenase, Corticosterone
  • Corticosterone 18 hydroxylase
  • Corticosterone 18 monooxygenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS

MeSH Record

History Note

2015 (1979)

MeSH Record

Previous Indexing

  • Cytochrome P-450 (1984-1996)
  • Desoxycorticosterone (1979-1982)
  • Steroid 11 beta-Monooxygenase (1994-1996)
  • Steroid Hydroxylases (1979-1993)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.484.500
  2. D08.244w.453w.915w.050
  3. D08.811w.682w.690w.708.170w.425.500
  4. D08.811w.682w.690w.708.170w.915w.050
  5. D12.776w.422w.220w.453w.484.500
  6. D12.776w.422w.220w.453w.915w.050

AMA Style

References

  1. National Library of Medicine. Cytochrome P-450 CYP11B2. Medical Subject Headings (MeSH). 2026. Unique ID D019405. http://id.nlm.nih.gov/mesh/2026/D019405
  2. Cytochrome P-450 CYP11B2. In: Wikidata. https://www.wikidata.org/wiki/Q58623239